Opening of Mitochondrial K ATP Channels Triggers Cardioprotection
نویسندگان
چکیده
منابع مشابه
Opening of mitochondrial K(ATP) channels triggers cardioprotection. Are reactive oxygen species involved?
Ischemic preconditioning, a phenomenon in which brief episodes of ischemia and reperfusion paradoxically protect the heart against subsequent lethal ischemia,1 has been conceptually divided into triggers and mediators/effectors.2,3 The trigger, which acts before the index ischemia, is followed by the protection of mediators/effectors during the lethal ischemia. Known triggers include activation...
متن کاملRole of the mitochondrial ATP-sensitive K+ channels in cardioprotection.
The mitochondrial ATP-sensitive K(+) (mitoK(ATP)) channel was discovered more than a decade ago. Since then, several pharmacological studies have identified agents that target this channel some of which selectively target mitoK(ATP). These and other studies have also suggested that mitoK(ATP) plays a key role in the process of ischemic preconditioning (IPC) and prevention of apoptosis. The mech...
متن کاملOpening of mitochondrial K(ATP) channels triggers the preconditioned state by generating free radicals.
The critical time for opening mitochondrial (mito) K(ATP) channels, putative end effectors of ischemic preconditioning (PC), was examined. In isolated rabbit hearts 29+/-3% of risk zone infarcted after 30 minutes of regional ischemia. Ischemic PC or 5-minute exposure to 10 micromol/L diazoxide, a mito K(ATP) channel opener, reduced infarction to 3+/-1% and 8+/-1%, respectively. The mito K(ATP) ...
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The present study was undertaken to investigate the protective effect of H2S against myocardial ischemia-reperfusion (I/R) injury and its possible mechanism by using isolated heart perfusion and patch clamp recordings. Rat isolated hearts were Langendorff-perfused and subjected to a 30-minute ischemia insult followed by a 30-minute reperfusion. The heart function was assessed by measuring the L...
متن کاملMitochondrial ATP-dependent potassium channels: novel effectors of cardioprotection?
BACKGROUND Brief interruptions of coronary blood flow paradoxically protect the heart from subsequent prolonged ischemia. The basis of such endogenous cardioprotection, known as "ischemic preconditioning," remains uncertain. Pharmacological evidence has implicated ATP-dependent potassium (KATP) channels in the mechanism of preconditioning; however, the effects of sarcolemmal KATP channels on ex...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2001
ISSN: 0009-7330,1524-4571
DOI: 10.1161/hh0801.090537